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Research on collagen continues to evolve – and the latest studies show that this central protein is not only important for skin structure and elasticity, but also for gut health and the immune system . In this article, we summarize news from the latest published research and what it can mean for those of you who want to strengthen your body's structure, barriers and general vitality.
Collagen is the body’s most abundant protein and is found in connective tissue, skin, tendons, bones and intestinal walls. It acts as a kind of “glue” that holds tissues together and gives them strength and flexibility. Over time, the body’s own collagen production decreases and its breakdown increases – affecting skin firmness, intestinal barrier function and immune system balance.
A systematic review published in 2025 examined the effect of collagen supplements on skin aging (elasticity, hydration, wrinkles) by analyzing 23 randomized controlled trials with a total of 1,474 participants. The conclusion was that supplements showed significant improvements in skin hydration, elasticity, and wrinkle status. PubMed +2 ScienceDirect +2
Another 2025 study examined how collagen peptides combined with vitamin D and calcium affected bone and muscle health. It found that supplementation could increase bone mineral density (BMD) and muscle performance—especially when combined with vitamin D and calcium. PMC
A third review highlighted that oral collagen may also have positive effects on the intestinal barrier and gut health, including by supporting a balanced intestinal flora and reducing inflammatory processes. SpringerOpen
Skin: Improved hydration and elasticity suggest that collagen supplementation can strengthen extracellular tissue and reduce visible signs of aging.
Gut & Immune System: A healthy gut flora and an intact intestinal barrier are crucial for the absorption of nutrients for collagen production and for the immune system to function without overreactions. Research indicates that collagen can also help strengthen the structure of the gut and thereby support the immune system.
Bones & Muscles: Although the focus is often on skin, other recent research shows that collagen can also be a valuable support for cartilage, tendons and bones – especially when combined with nutrients like vitamin D and calcium.
Choose a high-quality collagen supplement with documented bioavailability (preferably hydrolyzed collagen peptide).
Combine with a good diet: ensure intake of vitamin C, zinc, copper, the amino acids glycine/proline and foods that support the intestinal flora (probiotics/prebiotics).
Think holistically – collagen production and tissue repair are supported by good sleep, stress management and regular physical activity.
Research shows that effects are often seen with daily intake for several weeks.
Have realistic expectations: Studies show positive effects, but the effect varies – and supplements are not a substitute for a healthy lifestyle.
Recent research reinforces the image of collagen as a multifunctional building block for the body's connective tissue - from skin to gut and immune system. At Celloptimum, we see this as confirmation that integrated health (diet, gut flora, sleep, lifestyle) is the path to real results. By supporting collagen production, nurturing gut health and optimizing the immune system, you create a stronger foundation for long-term health and vitality.
